Comments for MigraineNews.co.uk http://migrainenews.co.uk News, comment and information about migraine from a practising neurologist Fri, 29 Aug 2008 04:35:14 +0000 http://wordpress.org/?v=2.5 Comment on Migraine and Pregnancy checklist by Websites tagged "checklist" on Postsaver http://migrainenews.co.uk/2008/08/migraine-and-pregnancy-checklist/#comment-34 Websites tagged "checklist" on Postsaver Tue, 12 Aug 2008 20:00:03 +0000 http://migrainenews.co.uk/?p=38#comment-34 [...] - Migraine and Pregnancy checklist saved by shiashia2008-08-09 - Recovering from SDCC saved by [...] […] - Migraine and Pregnancy checklist saved by shiashia2008-08-09 - Recovering from SDCC saved by […]

]]> Comment on 7 Steps to Treat Migraine by 7 steps to treat migraine #3: Migraine and Exercise http://migrainenews.co.uk/migraine-7-steps/#comment-28 7 steps to treat migraine #3: Migraine and Exercise Fri, 18 Jul 2008 07:50:10 +0000 http://migrainenews.co.uk/?page_id=7#comment-28 [...] So a reminder of the seven simple steps to treat migraine: [...] […] So a reminder of the seven simple steps to treat migraine: […]

]]> Comment on 7 Steps to Treat Migraine by 7 steps to treat migraine #2: Hydration http://migrainenews.co.uk/2008/05/7-steps-treat-migraine/#comment-24 7 steps to treat migraine #2: Hydration Mon, 23 Jun 2008 06:01:34 +0000 http://migrainenews.co.uk/?p=8#comment-24 [...] can I read more about migraine headache treatment and prevention? This is part 2 in a series called 7-steps-to-treat-migraine. The 7 steps [...] […] can I read more about migraine headache treatment and prevention? This is part 2 in a series called 7-steps-to-treat-migraine. The 7 steps […]

]]> Comment on 7 Steps to Treat Migraine by MK0974 a new migraine treatment http://migrainenews.co.uk/migraine-7-steps/#comment-23 MK0974 a new migraine treatment Sat, 21 Jun 2008 07:23:15 +0000 http://migrainenews.co.uk/?page_id=7#comment-23 [...] What is MK0974? It is a new migraine treatment. How does MK0974 work? It works by preventing the release of the pain-inducing chemical CRGP. At the beginning of a migraine attack, CRGP is released into the lining of the brain (the meninges). CRGP starts a series of unfortunate events, called neurogenic inflammation, within the meninges. It is this neurogenic inflammation of the lining of the brain that leads to the intense pain of migraine. The theory is that if you can stop CRGP from getting out, you may block the development of neurogenic inflammation, and stop the migraine pain in its tracks. How do we know that MK0974 really does work? To develop the drug its license holders - Merck - have conducted several large studies. The largest and most recent is due to announced next week, June 26th-29th at the American Headache Society Meeting in Boston. A similar compound called BIBN 4096 BS has previously been researched as a migraine treatment, published in the New England Journal of Medicine. The final results of the most recent migraine treatment research on MK0974 are due next week at the American Headache Society Meeting in Boston, and the rumbles in the jungle are that it might prove to have a powerful efect in treating migraine headache. How is MK0974 taken? In the research studies, Merck used a 150mg and 300mg gel-filled capsule. So it would be a capsule that is swallowed. I have migraine, when will I be able to get hold of MK0974? To be able to get hold of MK0974 as a regular prescription from your doctor or neurologist, MK0974 will have to be approved by the FDA as a migraine treatment. Once approved, you could obtain it from your doctor in the usual way. Sometimes a compassionate use scheme is set up by the manufacturer. Ina compassionate use scheme, a drug with proven efficacy, but which is still going through FDA approval, can be made available on a “named-patient basis” to people who have no other option. It can take a year or even more, to get FDA approval. I do not know if Merck are planning a compassionate use scheme. I have migraine, will MK0974 be suitable for me? You need to remember that there are already a lot of proven treatments for migraine attacks out there: Aspirin, metoclopramide, prochlorperazine, Migraleve, Anadin, Tolfenamic Acid, Sumatriptan, Zomig etc etc etc. To begin with I would anticipate reserving MK0974 for people with migraine who have had no benefit from the alternatives or in whom the alternatives are contr-indicated. Will MK0974 prevent migraine? As far as I can tell, this drug will not prevent migraine, but is designed to stop a migraine from building into a full-blown attack. Please remember that if you are having a lot of migraine attacks to take steps to ensure that you are looking after yourself properly - don’t make migraine a drug-fest - look after yourself better. Remember migraine-7-steps? [...] […] What is MK0974? It is a new migraine treatment. How does MK0974 work? It works by preventing the release of the pain-inducing chemical CRGP. At the beginning of a migraine attack, CRGP is released into the lining of the brain (the meninges). CRGP starts a series of unfortunate events, called neurogenic inflammation, within the meninges. It is this neurogenic inflammation of the lining of the brain that leads to the intense pain of migraine. The theory is that if you can stop CRGP from getting out, you may block the development of neurogenic inflammation, and stop the migraine pain in its tracks. How do we know that MK0974 really does work? To develop the drug its license holders - Merck - have conducted several large studies. The largest and most recent is due to announced next week, June 26th-29th at the American Headache Society Meeting in Boston. A similar compound called BIBN 4096 BS has previously been researched as a migraine treatment, published in the New England Journal of Medicine. The final results of the most recent migraine treatment research on MK0974 are due next week at the American Headache Society Meeting in Boston, and the rumbles in the jungle are that it might prove to have a powerful efect in treating migraine headache. How is MK0974 taken? In the research studies, Merck used a 150mg and 300mg gel-filled capsule. So it would be a capsule that is swallowed. I have migraine, when will I be able to get hold of MK0974? To be able to get hold of MK0974 as a regular prescription from your doctor or neurologist, MK0974 will have to be approved by the FDA as a migraine treatment. Once approved, you could obtain it from your doctor in the usual way. Sometimes a compassionate use scheme is set up by the manufacturer. Ina compassionate use scheme, a drug with proven efficacy, but which is still going through FDA approval, can be made available on a “named-patient basis” to people who have no other option. It can take a year or even more, to get FDA approval. I do not know if Merck are planning a compassionate use scheme. I have migraine, will MK0974 be suitable for me? You need to remember that there are already a lot of proven treatments for migraine attacks out there: Aspirin, metoclopramide, prochlorperazine, Migraleve, Anadin, Tolfenamic Acid, Sumatriptan, Zomig etc etc etc. To begin with I would anticipate reserving MK0974 for people with migraine who have had no benefit from the alternatives or in whom the alternatives are contr-indicated. Will MK0974 prevent migraine? As far as I can tell, this drug will not prevent migraine, but is designed to stop a migraine from building into a full-blown attack. Please remember that if you are having a lot of migraine attacks to take steps to ensure that you are looking after yourself properly - don’t make migraine a drug-fest - look after yourself better. Remember migraine-7-steps? […]

]]> Comment on 7 Steps to Treat Migraine by What’s the fuss about Tonabersat? http://migrainenews.co.uk/migraine-7-steps/#comment-21 What’s the fuss about Tonabersat? Sat, 21 Jun 2008 06:14:43 +0000 http://migrainenews.co.uk/?page_id=7#comment-21 [...] What’s the fuss about tonabersat? Tonabersat is in the news. Last week, its developers, Westminster Pharmaceuticals, announced that it had managed to reach a crucial stage in the testing of the drug. They needed 500 people to take part in their research study, and that goal has now been achieved. Why does this matter? It matters because unless you can a large number of human volunteres, you will never be able to prove a drug works. Westminster are now able to test the drug properly. They intend to be able to report the full findings mid-2009. It also matters to their investors who will be anxious about whether this compund will ever see the light of day as a viable migraine treatment. How does Tonabersat work? Tonabersat started out in the late 1990s as an experimental treatment for epilepsy. However, research showed that it did not have good potential to treat epilepsy. Migraine and epilepsy are both conditions of hyperactivity or hypersensitivity of the surface of the brain (the cerebral cortex). So the developers (I’m pretty sure it was Glaxo-Smith-Klein) then thought it might be a useful migraine prevention drug. The traditional types of migraine prevention drug are beta-blockers, anti-convulsants and anti-depressants. Tonabersat is a new type of migraine prevention drug. It works by stopping chemical interaction between cells - by blocking a zone between brain cells called the gap junction. Should I try and get Tonabersat to treat my migraine headache? At the moment no - it is not available outside the trial being run (called the Tempus IIb study). Remember that treating migraine headche is not just about drugs - a lot of it is about looking after yourself : a good sleep pattern, keeping hydrated, regular gentle exercise, weight management/diet and stress avoidance. Medicines are only part, albeit an important one, of the picture. Remember Migraine-7-steps! [...] […] What’s the fuss about tonabersat? Tonabersat is in the news. Last week, its developers, Westminster Pharmaceuticals, announced that it had managed to reach a crucial stage in the testing of the drug. They needed 500 people to take part in their research study, and that goal has now been achieved. Why does this matter? It matters because unless you can a large number of human volunteres, you will never be able to prove a drug works. Westminster are now able to test the drug properly. They intend to be able to report the full findings mid-2009. It also matters to their investors who will be anxious about whether this compund will ever see the light of day as a viable migraine treatment. How does Tonabersat work? Tonabersat started out in the late 1990s as an experimental treatment for epilepsy. However, research showed that it did not have good potential to treat epilepsy. Migraine and epilepsy are both conditions of hyperactivity or hypersensitivity of the surface of the brain (the cerebral cortex). So the developers (I’m pretty sure it was Glaxo-Smith-Klein) then thought it might be a useful migraine prevention drug. The traditional types of migraine prevention drug are beta-blockers, anti-convulsants and anti-depressants. Tonabersat is a new type of migraine prevention drug. It works by stopping chemical interaction between cells - by blocking a zone between brain cells called the gap junction. Should I try and get Tonabersat to treat my migraine headache? At the moment no - it is not available outside the trial being run (called the Tempus IIb study). Remember that treating migraine headche is not just about drugs - a lot of it is about looking after yourself : a good sleep pattern, keeping hydrated, regular gentle exercise, weight management/diet and stress avoidance. Medicines are only part, albeit an important one, of the picture. Remember Migraine-7-steps! […]

]]> Comment on Migraine International #1 by Jennifer Lancey http://migrainenews.co.uk/2008/06/migraine-india/#comment-11 Jennifer Lancey Sun, 01 Jun 2008 00:52:50 +0000 http://migrainenews.co.uk/?p=19#comment-11 Hello there. I was sent a link to your blog by a friend a while ago. I have been reading a long for a while now. Just wanted to say HI. Thanks for putting in all the hard work. Jennifer Lancey Hello there. I was sent a link to your blog by a friend a while ago. I have been reading a long for a while now. Just wanted to say HI. Thanks for putting in all the hard work.

Jennifer Lancey

]]> Comment on Journals latest by MigraineNews.co.uk » Blog Archive » What is MigraineNews.co.uk? http://migrainenews.co.uk/journals-latest/#comment-10 MigraineNews.co.uk » Blog Archive » What is MigraineNews.co.uk? Sun, 01 Jun 2008 00:30:00 +0000 http://migrainenews.co.uk/?page_id=11#comment-10 [...] for you. It will also contain technical items for professionals with an interest in migraine ( e.g. Journals latest). If you are a writer, then this site will contain newsworthy updates, useful links and resources - [...] […] for you. It will also contain technical items for professionals with an interest in migraine ( e.g. Journals latest). If you are a writer, then this site will contain newsworthy updates, useful links and resources - […]

]]> Comment on 7 Steps to Treat Migraine by MigraineNews.co.uk » Blog Archive » 7 steps to treat migraine #1: Sleep http://migrainenews.co.uk/migraine-7-steps/#comment-9 MigraineNews.co.uk » Blog Archive » 7 steps to treat migraine #1: Sleep Sun, 01 Jun 2008 00:29:20 +0000 http://migrainenews.co.uk/?page_id=7#comment-9 [...] 7 Steps to Treat Migraine [...] […] 7 Steps to Treat Migraine […]

]]> Comment on 7 Steps to Treat Migraine by MigraineNews.co.uk » Blog Archive » Can anyone fix my sinus headache? http://migrainenews.co.uk/migraine-7-steps/#comment-3 MigraineNews.co.uk » Blog Archive » Can anyone fix my sinus headache? Wed, 28 May 2008 04:27:52 +0000 http://migrainenews.co.uk/?page_id=7#comment-3 [...] 7 simple steps [...] […] 7 simple steps […]

]]> Comment on 7 Steps to Treat Migraine by Neurology Information » Blog Archive » Migraine aura - tingling, numbness, weakness, visual disturbance http://migrainenews.co.uk/migraine-7-steps/#comment-2 Neurology Information » Blog Archive » Migraine aura - tingling, numbness, weakness, visual disturbance Tue, 13 May 2008 20:41:22 +0000 http://migrainenews.co.uk/?page_id=7#comment-2 [...] less tired, hydrated, eat regularly and reduce stress, migraine aura is less likely to happen. See 7 simple steps to treating migraine for more detail. If you still get frequent migraine aura, preventative medicines may help. Tablets [...] […] less tired, hydrated, eat regularly and reduce stress, migraine aura is less likely to happen. See 7 simple steps to treating migraine for more detail. If you still get frequent migraine aura, preventative medicines may help. Tablets […]

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